ある一定の確率でLegendaryな敵が出現します。Legendaryは伝説級といえるほど強い能力を持っており、少なくとも耐久性は普通の敵の4倍程度は有ります。(序盤であればドクロマークが付いていることがほとんど、これは格上の敵を表しています。)
Legendaryの敵を倒すと"必ずLegendaryの効果のついた武器か防具をドロップします。"
効果がそれぞれ違うため、また武器との相性によっては相当強力なものになります。もちろんハズレ的な効果になることがほとんどです。
ユニーク武器・防具は特定のNPCが持っている武器です。ボス級の敵が持っていたり、NPC商人が販売していたりします。
扱い的にはLegendaryの武器防具と変わりありませんが、名前がユニーク固定となっていますので効果をきちんと確認しましょう。
(暫定:英語から未翻訳ですが効果一覧です)
| Assassin's | Does 50% more damage against humans |
| Automatic | Automatic fire mode. (Laser Musket only) |
| Berserker's | Does more damage the lower the player character's Armor Resistance. (Up to 200% at 0 resistance) |
| Bloodied | Does more damage the lower the health is. |
| Cavalier's | Reduces damage by 15% while blocking or sprinting. |
| Crippling | 50% more limb damage |
| Enraging | Critical hits cause target to frenzy. |
| Explosive | Bullets explode on impact doing 15 points area-of-effect damage |
| Exterminator's | Does 50% more damage against Mirelurks and bugs |
| Freezing | Does 10 points cryo damage and will freeze targets on critical hits. |
| Furious | Increased damage after each consecutive hit on the same target. |
| Ghoul slayer's | Does 50% more damage against ghouls. |
| Hunter's | Does 50% more damage against animals |
| Incendiary | Sets target on fire for 15 points of damage. |
| Instigating | Does double damage if the target is at full health. |
| Irradiated | Does 50 points additional radiation damage. |
| Junkie's | Does increased amounts of damage the more withdrawal effects the Sole Survivor is suffering. |
| Kneecapper | 20% chance to cripple the target's leg. |
| Lucky Weapon | Critical shots do double damage and the critical meter fills 15% faster |
| Medic's | Heals target instead of hurting them. |
| Mighty | Deals an additional 25% damage. |
| Mutant slayer's | Does 50% more damage against Super Mutants. |
| Never Ending | Sets ammo capacity equal to the amount one is carrying. |
| Nimble | Provides 75% faster movement while aiming. |
| Nocturnal | Does increasing amounts of damage as the night grows longer and less damage during the day. |
| Penetrating | Ignores 30% of the target's damage and energy resistance. |
| Plasma infused | Adds 10 points of energy damage and can turn enemies into goo. |
| Poisoner's | Target is poisoned for 10 seconds. |
| Powerful | Provides 25% more damage. |
| Quickdraw | Costs 25% fewer Action Points. |
| Rapid | 25% faster fire rate, 15% faster reload. |
| Relentless | Refills Action Points on a critical hit. |
| Sentinel's | Take 15% less damage while standing and not moving. |
| Staggering | Chance to stagger on hit. |
| Stalker's | If not yet in combat, increases V.A.T.S. accuracy but costs more AP. |
| Troubleshooter's | Does 50% more damage against robots. |
| Two shot | Fires an additional projectile. Decrease in accuracy. |
| VATS enhanced | Improved V.A.T.S. hit chance, 25% less Action Point cost. |
| VATS enhanced | 40% less Action Point cost. |
| Violent | Deals +25% damage and limb damage, but has more recoil. |
| Wounding | Targets bleed for 25 points of additional damage. |
楽しいのはRapid・Explosiveをフルオート改造してのトリガーハッピー。
(暫定:英語から未翻訳ですが効果一覧です)
| Acrobat's | Reduces falling damage by 50%. |
| Almost Unbreakable | Quadruples durability (power armor only). |
| Assassin's | Reduces damage from humans by 15%. |
| Bolstering | Grants increasing energy and damage resistance the lower your Health (up to +35). |
| Cavalier's | Reduces damage while blocking or sprinting by 15%. |
| Chameleon | Enemies have a harder time detecting you while you're sneaking and not moving. |
| Cunning | +1 Agility and +1 Perception |
| Duelist's | 10% chance to disarm melee attacker on hit. |
| Exterminator's | Reduces damage from Mirelurks and bugs by 15%. |
| Fortifying | +1 Strength and +1 Endurance |
| Freefall | Prevents falling damage.(Needs to be present on both equipped leg armors) |
| Ghoul slayer's | Reduces damage from ghouls by 15% |
| Hunter's | Reduces damage from animals by 15%. |
| Low Weight | Low carry weight. |
| Lucky | +2 Luck. |
| Martyr's | Temporarily slows time down during combat when you are at 20% or less Health. |
| Mutant Slayer's | Reduces damage from super mutants by 15%. |
| Piezonucleic Lining | Radiation exposure increases Action Point refresh speed. |
| Poisoner's | +25 poison resistance. |
| Powered | Increases Action Point refresh speed. |
| Punishing | Reflects 10% of melee damage back on attacker. |
| Safecracker's | Increases size of sweet spot while picking locks. |
| Sharp | +1 Charisma and +1 Intelligence. |
| Sprinter's | Increases movement speed by 10%. |
| Titan's / Sentinel's | Reduces damage while standing and not moving by 15%. |
| Troubleshooter's | Reduces damage from robots by 15%. |
| VATS Enhanced | 10% reduction in Action Point cost in V.A.T.S. |